PA: Viewer discretion is advised.

MICHAEL AND THE ESCAPE GANG BEGIN THE RUN FOR THEIR LIVES AS A NEW FBI AGENT LEADS THE HUNT FOR THEIR CAPTURE ON THE SEASON PREMIERE OF "PRISON BREAK" ENCORING WEDNESDAY, AUGUST 23, ON FOX

Picking up eight hours after their escape from Fox River, Michael, Lincoln, Sucre, Abruzzi and C-Note are on the run for their lives as a vengeful Bellick leads the prison guards seeking to capture their escaped quarry; Dr. Sara is in critical condition from her overdose; Veronica finds herself a prisoner with Terrance; T-Bag tries to get the upper hand while fleeing from the authorities; and a new take-charge FBI investigator proves to be Scofield's match in "Manhunt," the season-premiere episode of PRISON BREAK, encoring Wednesday, Aug. 23 (9:00-10:00 PM ET/PT) on FOX. (PB-201) (TV-14 D, L, V)

Cast: Dominic Purcell as Lincoln Burrows; Wentworth Miller as Michael Scofield; Robin Tunney as Veronica Donovan; Amaury Nolasco as Fernando Sucre; Marshall Allman as LJ Burrows; Wade Williams as Captain Brad Bellick; Paul Adelstein as Special Agent Paul Kellerman; Robert Knepper as T-Bag; Rockmond Dunbar as C-Note and Sarah Wayne Callies as Dr. Sara Tancredi with Bill Fichtner as Special Agent Alexander Mahone.

Guest Cast: Peter Stormare as John Abruzzi; Stacy Keach as Warden Henry Pope.